Molecular Formula | C16H23NO4 |
Molar Mass | 293.36 |
Density | 1.160±0.06 g/cm3(Predicted) |
Boling Point | 559.5±50.0 °C(Predicted) |
Solubility | 10 mM in DMSO |
pKa | 13.00±0.20(Predicted) |
Storage Condition | -20℃ |
In vivo study | Oral administration of RR6 in Wistar rats (150-200 g) completely inhibited plasma vanin activity and caused alterations of plasma lipid concentrations upon fasting. RR6 at 3 mg/mL in rats caused a nearly complete inhibition of plasma vanin. |
1mg | 5mg | 10mg | |
---|---|---|---|
1 mM | 3.409 ml | 17.044 ml | 34.088 ml |
5 mM | 0.682 ml | 3.409 ml | 6.818 ml |
10 mM | 0.341 ml | 1.704 ml | 3.409 ml |
5 mM | 0.068 ml | 0.341 ml | 0.682 ml |
biological activity | RR6 is a potent, selective, reversible, A competitive and orally active vanin inhibitor with an IC50 of 540 nM for recombinant vanin-1. RR6 also potently inhibited human, bovine and rat serum ubiquitin with IC50 values of 40 nM,41 nM and 87 nM, respectively. |